Blood protein-polymer adsorption: Implications for understanding complement-mediated hemoincompatibility
نویسندگان
چکیده
منابع مشابه
Protein Adsorption on Polymer Particles
Protein adsorption on polymer particles has significant importance in biomedical applications, both in vitro and in vivo. It has, therefore, been studied from all viewpoints for the last two decades, but the results were inconsistent due to its complexity. It is not an exaggeration to say that nobody knows what exactly happens at the interfaces between proteins and particles. Proteins are so la...
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Chitosan was recently indicated to enhance osteogenesis, improve wound healing but to activate the coagulation and the complement systems. In the present study approximately 10 nm thick chitosan film were prepared on aminopropyltriethoxysilane (APTES) coated silicon. The surfaces were incubated in serum or plasma and subsequently in antibodies towards key complement and contact activation of co...
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Protein adsorption at solid surfaces plays a key role in many natural processes and has therefore promoted a widespread interest in many research areas. Despite considerable progress in this field there are still widely differing and even contradictive opinions on how to explain the frequently observed phenomena such as structural rearrangements, cooperative adsorption, overshooting adsorption ...
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The clinical management of paroxysmal nocturnal hemoglobinuria (PNH), a rare but life-threatening hematologic disease, has fundamentally improved with the introduction of a therapeutic that prevents complement-mediated intravascular hemolysis. However, a considerable fraction of PNH patients show insufficient treatment response and remain transfusion dependent. Because the current treatment onl...
متن کاملAdsorption Theory for Polymer Molecules
well as polymer and surface. See, for example, the definition of E preceding Eq. (40) of FH-2. In the plateau region, on the other hand, adsorption was predicted to be molecular weight independent. Considering the approximations involved, it would probably be more realistic to simply assert that molecular weight dependence is small. The predicted increase in the adsorption plateau with increasi...
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ژورنال
عنوان ژورنال: Journal of Biomedical Materials Research Part A
سال: 2011
ISSN: 1549-3296
DOI: 10.1002/jbm.a.33030